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The best characterized intracellular substrates for the insulin and IGF-I receptors are the insulin receptor substrate proteins 1 to 4[250]

The administration of cytostatics to humans is followed by cardiotoxicity due to increased plasma levels of ROS and lipid peroxidation products and decreased plasma and tissue levels of antioxidants

[DOI] [PubMed] [Google Scholar] 26.Esposito K, Nappo F, Marfella R, Giugliano G, Giugliano F, Ciotola M, et al

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Increased mitochondrial electron transport chain activity at complex i is regulated by N-acetylcysteine in lymphocytes of patients with systemic lupus erythematosus