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JAK inhibitors, such as Baricitinib and Tofacitinib, are small molecule drugs that hinder neutrophil migration and ROS generation by suppressing the secretion of inflammatory factors (68)
Achieving sufficient tumor selectivity while sparing normal brain tissue remains a critical unresolved challenge for ferroptosis-based therapies in GBM

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The various aspects of genetic and epigenetic toxicology: testing methods and clinical applications

77 : 850859 DeRubertis FR, Craven PA and Saito R
