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Human CBS adopts a unique multi-domain structure: an N-terminal haem binding domain (residues 3874), a central PLP-dependent catalytic domain (CD, residues 75382), and a C-terminal regulatory domain (RD, residues 411551) 5,11,12 (Fig

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10.1016/j.phymed.2022.154306 14 CakilB.BasarF

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doi: 10.1111/ajt.12387 53 HalloranPFReeveJAkalinEAubertOBohmigGABrennanDet al

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Uric acid as a mediator of endothelial dysfunction, inflammation, and vascular disease

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Confirming normal baseline organ function is a mandatory pretreatment assessment before safely initiating standard disease-modifying antirheumatic drugs (DMARDs) like methotrexate, which is strictly contraindicated in cases of liver disease or severe kidney impairment (Cohen & Mikuls, 2025

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