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The first nootropic to use the term was a drug developed in the 1960s called piracetam.60 61 It was intended to treat anxiety and provide patients with a soothing experience that might even lull them to sleep.2 The effect was quite different than what its creators intended, as users reported sharper focus, and later testing pointed toward improved memory

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Copper peptides GHK-CU similarly target collagen synthesis through different mechanisms and are sometimes used alongside GLP-1 therapy for skin quality