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Parallel reporter assays identify altered regulatory role of rs684232 in leading to prostate cancer predisposition
Additionally, in lung cancer, hyperactivation of Nrf2 enables cancer cells to regulate intracellular iron metabolism more effectively, thereby inhibiting iron-dependent lipid peroxidation and evading ferroptosis [10]

LGSH derived from MGO is subsequently hydrolyzed by glyoxalase 2 (GLO2) to produce D-lactate and glutathione [33]

doi: 10.1016/S0014-2999(99)00782-7
