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Full structural repair, if imaging is used to assess it, typically requires eight to twelve weeks

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Pubertal delay and reduced pubertal growth spurts are characteristic findings of longstanding ESRD and probably result from the reduced release of hypothalamic gonadotropin-releasing hormone (GnRH) and decreased circulating levels of bioactive luteinizing hormone (LH) due to CKD-related inhibitory factors such as angiotensin II 29

This makes them especially useful for individuals who have difficulty absorbing vitamins through the digestive tract or those with certain conditions that impair nutrient absorption