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3.4.3 Incentive mechanisms for the adaptation of FBS alternatives The reduction and replacement of FBS use with alternatives are becoming feasible as hPL and other serum-free substitutes have demonstrated performance comparable to that of FBS, supporting MSCs proliferation without compromising phenotypic stability, and enhancing monoclonal antibodies production in hybridoma cell lines (Even et al., 2006

It is involved in the assimilation of nutrients, the regulation of the immune response as well as in the protection of oxidative stress

An inducible cytochrome P4503A4-dependent vit D catabolic pathway

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However, a concomitant decrease in glutamine uptake within cancer cells has been demonstrated to meet the demand for glutamine by lymphocytes within the tumor mesenchyme