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For example, dupilumab was approved by the FDA and the EMA (EU) for adults with moderate-to-severe AD
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These pregnancies are associated with higher risk of complications and poorer outcomes
These pathways include BCL-XL, the cell cycle inhibitor p21, the ephrins EFNB1 and EFNB3, serpin PAI1, the oxygen sensor HIF-1 and phosphatidylinositol 3-kinase-delta (PI3K)
