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It Just Needs the Signals Restored

EPI-743 reverses the progression of the pediatric mitochondrial diseasegenetically defined Leigh syndrome

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Depletion of adenosine has been shown to reduce fibrosis, inflammation, and vasculopathy in two preclinical mouse models of SSc 61

Inhibition of glutamine formation and retention in rat brain slices by ouabain (Benjamin, Regardless of detailed mechanisms involved, ATP requirement for glutamine synthesis and ammonia uptake in astrocytes and for glutamine (or GABA) uptake in neurons makes neuronal transmitter supply from astrocytes an approximately twothree times more expensive process than neuronal production or uptake from the extracellular fluid would have been