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Abbreviations 4-PB: 4-phenylbutyrate A1AT: Alpha 1-antitrypsin ABC: ATP-binding cassette AFP: Alpha-fetoprotein ASBT: Apical sodium dependent bile acid transporter BAs: Bile acids BSEP: Bile salt export pump CA: Cholic acid CDCD: Chenodeoxycholic acid CYP: Cytochrome P450 DCA: Deoxycholic acid DCDC2: Doublecortin domain containing 2 FGFR4: fibroblast growth factor receptor 4 FXR: farnesoid X receptor G(T)CA: Glyco- or tauro-cholic acid G(T)CDCA: Glyco- or tauro-chenodeoxy cholic acid GGT: Gamma glutamyl transpeptidase HCC: Hepatocellular carcinoma IEBAM: Inborn error of bile acid metabolism LCA: Lithocholic acid MDR2/3: Multidrug resistance protein 2/3 MRP2/3/4: Multidrug resistance-associated protein 2/3/4 MYO5B: Myosin VB NASH: Nonalcoholic steatohepatitis NH: Neonatal hepatitis NICCD: Neonatal cholestasis caused by citrin deficiency NTCP: Sodium/taurocholate co-transporting polypeptide OATP1B1/3: Organic-anion-transporting polypeptide 1B1 and 1B3 OST/: Organic solute transporter-/ PC: Phosphatidylcholine PFIC: Progressive familial intrahepatic cholestasis PS: Phosphatidylserine RXR: Retinoid X receptor SERPINA1: Serpin family A member 1 SHP: Small heterodimer partner TFAM: Mitochondrial transcription factor A TGR5: Takeda G protein-coupled receptor 5 (G protein-coupled bile acid receptor 1 , GPBAR1) TJP2: Tight junction protein 2 UDCA: Ursodeoxycholic acid UGT1A1: UDP-glucuronosyltransferase 1A1 References Esteller A

For IV administration, a dose is usually 10-20 mg per kilogram of body weight

This matters because it suggests the effect described above is likely most meaningful during genuine, more significant fluid loss not the ordinary hydration ups and downs of a typical day