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It is important to distinguish between correlation and causation

Preclinical and animal studies validate the clinical findings on AOD 9604 by demonstrating its clear impact on fat metabolism and 3-adrenergic receptor activity

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Supplementation of butyrate (all Sigma-Aldrich, Germany) was done in the drinking water at a final concentration of 150 mM and changed every 3 days and control mice received pH and sodium-matched water

Conversely, the group with lower MET exhibited a mere 50.9% PFS rate over six months [147]