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PMCID: PMC5834427

Metabolic reprogramming, as one of the important pathogenetic mechanisms of DKD, needs to be further investigated
High methyl-group demand Creatine synthesis, phosphatidylcholine synthesis, detoxification and numerous methyltransferase reactions compete for SAM-derived methyl groups

Because these peptides influence growth hormone and IGF-1 signaling, monitoring matters

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