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Tissue adapts through stress, load, time, sleep, and metabolic support, not simply through molecular signaling

Therefore, the biological state, dosages, splicing isoforms of VEGF and delivery method of the exogenous VEGF are the most important factors for determining whether exogenous VEGF is beneficial for tendon healing

One of the receptors that VEGF binds to is VEGFr-2

This is easy to do as the lungs give little warning through pain until they do burst