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Description
The last enzyme in this pathway, methylmalonyl-CoA mutase, requires vitamin B12 as a cofactor in the conversion of methylmalonyl-CoA to succinyl-CoA which then enters the TCA cycle
Therefore, using antidepressants, GABA analogs, opioids, and topical agents to treat pain in PDN is recommended
Several factors have been suggested to affect ROS levels in cells, including hypoxia, ER stress, metabolic alteration, and oncogenes [3]
CGI-I, Clinical Global Impression Scale for Improvement
The European Union (EU) Joint Programme-Neurodegenerative Disease Research (JPND) states that by the year 2030, a quarter (25%) of the European population will be over age 65, a significant increase over the current 16% [1]
