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doi: 10.1093/humupd/dmx028 Summary Keywords preterm premature rupture of membranes (PROM), vaginal microecology, bacterial vaginosis (BV), inflammation, oxidative stress Citation Deng Y, Li Y, Liu T and Wu F (2025) Interaction of vaginal microbiota and biomarkers in Premature rupture of membranes: from bench to beside

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However, in another intervention trial with combination therapy (53), the risk of adverse effects was significantly higher in the Se supplementation group, which we speculate may be related to unclear baseline Se levels in the subjects and a narrower safety window during Se treatment