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The AGEs content was markedly lower in Fru + amlodipine (33%), Fru + aminoguanidine (27%), and Fru + NAC (2%) than in Fru

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Most of the residues were well-resolved, except for the N-terminal methionine residue

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Some peptides may be cycled (used in intervals) with off-periods, while others may be used more continuously under supervision

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Funding This work was supported by the National Natural Science Foundation of China (82573571, 82470594), the National Science and Technology Major Project (2025ZD0545300), the Shanghai 2025 Basic Research Plan Natural Science Foundation (25ZR1401393), the Key Project of the Heilongjiang Provincial Joint Fund of the Natural Science Foundation (ZL2025H017), and the First Batch of Open Topics of the Shanghai Key Laboratory of Nautical Medicine and Translation of Drugs and Medical Devices (2025QN13)

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The exact roles of FXN have not yet been completely elucidated, but scientific evidence indicates its role in iron-sulfur cluster (ISC) formation, iron homeostasis/binding, and heme biosynthesis [12-15]

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