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Future studies will be needed to elucidate the role of these metabolites in the behavioural anomalies in the 22q11.2DS mouse models

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To provide an example, these include curcumin, resveratrol, EGCG, and flavonoids which have consistently inhibited Akt phosphorylation and downstream mTORC1 activity in various cancer cell lines, such as prostate (PC 3), breast (MCF 7, MDA MB-231), colon (HT-29), and glioma (U251) cells which in many cases results in apoptosis or autophagy [139, 172, 197, 198]

M., Agius, L

In APP/PS1 mice, BBB permeability and pericyte number are reduced, and -amyloid induces mitochondrial autophagy-dependent ferroptosis via the CD36/PINK/PARKIN pathway, resulting in blood-brain barrier damage and contributing to AD