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However, when they looked at enzymes that give collagen its unique cross-linked structure within the ECM, they found that a family of these enzymes (the LOXL family) was more abundant in the fibrosis samples

Additionally, the TME hosts multiple innate immune cells, including myeloid-derived suppressor cells (MDSCs) and natural killer (NK) cells, which are modulated by cytokine signaling and can either support immune surveillance or contribute to immune dysfunction, ultimately leading to tumor progression