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Research programs NNMT inhibitor class development and optimization studies

After introduction of animal food, the cobalamin level increases and peaks at 37 years and then decreases, median plasma tHcy decreases and remains low until 7 years when it starts increasing, whereas median plasma MMA decreases after 12 months and remains low throughout childhood (Monsen et al., 2003)

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5-Amino-1MQ is the lead potent, selective small-molecule inhibitor of NNMT identified to date

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