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731 Pharmacological inhibition of USP14 effectively reduces the level of NCOA4 to protect neurons from ferritin-mediated ferroptosis
doi: 10.7150/thno.77089 243 LiCJXiaoYYangMSuTSunXGuoQet al
Johnstone, B
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The term ferroptosis was formally proposed in 2012, with mechanistic studies demonstrating erastins dual action in HT-1080 fibrosarcoma models: mitochondrial voltage-dependent anion channel (VDAC) modulation and inhibition of the Xc system subunit solute carrier family 7 member 11 (SLC7A11), leading to glutathione depletion and iron-dependent lipid ROS accumulation (Dixon et al., 2012)
