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More significant structural improvements reduced fine lines, improved firmness, better skin density typically become visible between weeks 8 and 12, with continued improvement through months 4 to 6 as collagen remodeling matures

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A total of seven patients were identified, all of whom received it following cardiac surgery

It also stimulates synthesis of decorin, a small proteoglycan involved in collagen regulation and wound healing, while promoting the formation of new blood vessels and recruiting immune cells to the wound site