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In earlier trials, some patients experienced common adverse effects like injection site pain, rash, headaches, muscle soreness, nausea and fevers

This behavior closely parallels the one found for humans living in the same area

Pennica, D., Hayflick, J

A calcium-dependent nitric oxide synthase and NMDA R1 glutamate receptor in the ink gland of Sepia officinalis: a hint to the regulatory role of nitric oxide in melanogenesis
Neuropsychiatric symptoms from vitamin B12 deficiency generally improve gradually with treatment, with noticeable changes beginning around 3 months after initiation and continuing for up to a year
