mitochondrial glutathione depletion Glutathione-depleting mitochondria-targeting nanodrugs for stress amplification and immune activation via synergistic photodynamic therapy and cuproptosis Summary. Depletion of glutathione (GSH)

In addition to diminishing the quality of life and independence, LLD is also associated with increased mortality (Fiske et al., 2009)

There is no universal best dosage

In the current study, KA administration exhibited reduced activation of PI3K/Akt/Nrf2, and increased levels of caspase-3 (total and activated)

Furthermore, SAC also restored the status of mitochondrial glutathione and glucose 6-phosphate dehydrogenase, ATP content, and the activity of mitochondrial respiratory complexes (I-IV) [109]

Regarding the enzymes that eliminate H 2 O 2 , the absence of specific genes responsible for peroxiredoxin (Prdx) and selenium-dependent Gpx enzymes enhances the vulnerability to cancer