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For example, mitochondrial metabolic disorder affects the alpha-ketoglutarate level, which in turn regulates the activities of ten-eleven-translocation (TET) and lysine demethylases (KDM), which, finally, affects the level of DNA and histone methylation [182]
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Concurrent application with highly acidic or strongly chelating topical agents-such as concentrated ascorbic-acid serums-may reduce the activity of one or both products because copper ions can catalyze oxidation reactions
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