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Nor do fiveor even fiftyloading doses provide long-lasting protection for people with other B12 absorption issues

Clinical translation requires human CSF pharmacokinetic assays to prove BBB bypass, a rigorous dose-escalation Phase I trial to establish a safe human NOAEL for chronic dosing, and an RCT utilizing precise neurocognitive testing (e.g., MoCA) to confirm that murine transcriptomic shifts yield functional neuroprotection in humans

Calcidiol is also lipophilic and can be stored within adipose tissue for several months

Each 10 units (0.1 mL) contains 500 mcg

* Results from a randomized double blinded study comparing the duration of hemodynamic responses to ephedrine and phenylephrine in patients undergoing lumbar spinal surgery while under propofol general anesthesia