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Zinc and selenium were also used in the treatment of PCOS based on the fact that serum zinc and selenium levels in women with PCOS are significantly lower than in healthy controls (139141)

Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus , Lancet 1, 785789 Randle PJ, Newsholme EJ & Garland PJ (1964), Effects of fatty acids, ketone bodies and pyruvate, and of alloxan-diabetes and starvation, on the uptake and metabolic fate of glucose in rat heart and diaphragm muscles , Biochem J 93, 652665 Rebouche CJ, Engel AG

Thus, we speculate that cisplatin or increased levels of 4-HNE induced by cisplatin stimulates GSTA4 activity in the inner ear of females, but not males, likely because the constitutive expression of inner ear Gsta4 mRNA is significantly higher in females than males and/or females have higher levels of estrogen

Biochim Biophys Acta 1830, 31393142 (2013)

Under physiological circumstances, the intracellular generation and scavenging of ROS is usually in homeostasis [27]