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Studies show that without ongoing medication: Most patients regain 75-90% of lost weight within two years Many report unusually strong hunger signals after discontinuation Metabolic adaptation makes weight maintenance significantly more challenging Of all the potential long-term effects, bone health deserves special attention because: Bone loss occurs silently : Unlike digestive side effects that are immediately noticeable, bone loss happens gradually with no symptoms until a fracture occurs The effects can be permanent : Once significant bone loss occurs, it can be difficult to fully restore The consequences are serious : Osteoporotic fractures can lead to chronic pain, disability, and in the case of hip fractures, a 20-30% mortality rate in the first year Combination risk factors : Many people taking GLP-1 medications already have other risk factors for osteoporosis, creating a perfect storm for bone health problems Also read: Does Ozempic Cause Osteoporosis

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Intestinal barrier dysfunction orchestrates the onset of inflammatory host-microbiome cross-talk in a human gut inflammation-on-a-chip