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Neurofibromin also associates with microtubules and plays a role in regulating GABA-ergic inhibitory neuronal activity in the hippocampus.7 RAS is a membrane-bound protein, and requires farnesylation (addition of a C15 isoprenoid to a cysteine residue near the C -terminus) for activity, a process that is catalyzed by farnesyltransferase

Drug Dev Res 56:428437 Kemp M, Go YM, Jones DP (2008) Nonequilibrium thermodynamics of thiol/disulfide redox systems: a perspective on redox systems biology