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30 g of mitochondrial matrix lysates were loaded/well

In the second part of the study, we compared the effects of long-term (four-day) exposure to DMSO on yeast cells with varying antioxidant system efficiency (wild type cells and sod1 and sod2 mutants) and with varying energy metabolism (aerobic, mixed respiratory-fermentative and fully fermentative metabolism) to identify cellular targets which are particularly sensitive to this xenobiotic

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The results of this study demonstrate that the PDIiNOSNOROS signaling axis plays a pivotal role in BSO-induced ferroptosis in a cell culture model, and also offer strategies for the selective manipulation (enhancement or suppression) of ferroptosis by targeting PDI or its downstream signaling elements

In this study, compared with groups HL and HLA, the HLG group exhibited increased hepatopancreas ACP activity, although the difference was not statistically significant, implying a potential beneficial effect of GSH supplementation in high-lipid diets on ACP activity