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Further experiments are needed to demonstrate if there is any direct proteinprotein interaction between Ycf1p and gGT similar to that observed between the human GGTL3B isoform of gGT and the plasma membrane-associated product of gene CT120 (He et al., 2002) or between yeast gGT and the vacuolar membrane protein of unknown function encoded by YOL137w
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Thus, larazotide acetate appears as a therapeutic option for diseases related to increased intestinal permeability [86]
