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10.1158/1078-0432.CCR-19-3975 250 YangJ.ZhouY.XieS.WangJ.LiZ.ChenL.et al (2021)

In contrast, the heart isoform is phosphorylated at the C-terminus by several protein kinases in different signaling pathways, resulting in enhancement of the PFK-2 kinase activity

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Secondarily, the thiolate oxidizability in most biomolecules is modulated by the adjacent basic groups, since protonation of any such group exerts an electron-withdrawing effect on the thiolate

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