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The serum VitB3 concentration was lower in the chemotherapy group.This may be due to nausea, vomiting and other side effects of chemotherapy that led to a decrease in the intake of VitB3 in food, or insufficient absorption of VitB3 due to diarrhea during chemotherapy

Sirtuins (SIRTs) represent a family of evolutionarily conserved enzymes that are dependent on NAD + , categorized into seven distinct members (SIRT1 through SIRT7) (Wan and Garg, 2021

investigated the effect of epithalamin on the pineal and serum melatonin levels in elderly rats
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Translation: the animal data is extremely strong, but the human data is basically anecdotal plus a couple of pilot studies
