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Cardiovascular disease and brain health: focus on white matter hyperintensities

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3.3.1 Parkinsons disease (PD) The primary pathologic hallmarks of PD are loss of dopaminergic neurons located in an area of the brain called the substantia nigra pars compacta, and the presence of Lewy bodies, intracellular aggregates of misfolded -synuclein, in dopaminergic neurons and likely contribute to the death of these neurons

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