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Notably, mRNA expression of Igfbp genes Igfbp2, Igfbp3 and Igfbp5 was found significantly depleted, and Igfbp4 levels significantly increased upon LLC challenge only in Igf1r fl/fl mice

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And with a combination this novel, the list of unknowns is long

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Genetic defects that cause abnormalities in this receptor or in a protein required for its expression at the cell surface result in a potentially fatal disease (familial glucocorticoid deficiency)

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