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Time-to-onset analysis Time-to-onset is defined as the time from the therapy start date (START_DT in the THER file) to the AE occurrence date (EVENT_DT in the DEMO file)

Results vary by individual based on age, genetics, baseline skin quality, and treatment adherence

The study result has shown that the expression of various enzymes involved in oxidative phosphorylation and ATP production (SLC25A5, ATP5B, ATP5A1) was decreased with time, indicating a gradual mitochondrial dysfunction that could contribute to the development of DKD (45)

Several studies demonstrated that injection of trace mineral solution could increase the concentration of trace minerals such as Cu and Se in liver for at least 2 weeks post injection in bovines (32, 33)

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