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This systematic review of the 13 controlled trials in 3,629 patients, involving 250 deaths, 220 cases of new heart failure, and 38 recurrent heart attacks, found that L-carnitine was associated with: Advertisement Significant 27% reduction in all-cause mortality (number needed to treat 38) Highly significant 65% reduction in ventricular arrhythmias (number needed to treat 4) Significant 40% reduction in the development of angina (number needed to treat 3) Reduction in infarct size There were numerically fewer myocardial reinfarctions and heart failure cases associated with L-carnitine, but this did not reach statistical significance.First author James J

[DOI] [PubMed] [Google Scholar] 304.Liu L, Aronson J, Huang S, Lu Y, Czernik P, Rahman S, Kolli V, Suva LJ, Lecka-Czernik B

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Neurology 74:691696 Koo DH, Ryu MH, Kim KM, Yang HK, Sawaki A, Hirota S, Zheng J, Zhang B, Tzen CY, Yeh CN, Nishida T, Shen L, Chen LT, Kang YK (2016) Asian consensus guidelines for the diagnosis and management of gastrointestinal stromal tumor