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To view a copy of this license, visit About this article Cite this article Duyvesteyn, H.M.E., Ren, J., Walter, T.S

1 2 Annual Review of Biochemistry

Its potent antioxidant properties help to neutralize free radicals that contribute to the signs of aging, such as wrinkles and fine lines

For instance, PGC1-related coactivators can activate the expression of NRF1, NRF2, and transcription factor A (TFAM, the final effectors of mtDNA transcription and replication) to regulate the expression of respiratory chain and the biogenesis of mitochondria, a process that has been well-documented in previous reviews (Gleyzer et al., 2005

This proximal position of the RAMP2 ECD is conserved in AMY 2 R complexes bound to CT peptides that also have a C-terminal Pro (P32 CT ) (Fig