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We examined whether Nrf1 and Nrf2 are important in the transcriptional regulation of the rat GCLC using Nrf1 and Nrf2 knockout (F1 and F2) and wild-type (WT) fibroblasts and found that Nrf1 and Nrf2 are important for the rat GCLC promoter activity despite absence of ARE
Two of these ALDH7A1 derived mRNAs each encode two proteins through the use of alternative in-frame translation initiation codons
10.1016/j.diabres.2013.11.002 146
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