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Interestingly, enzymes such as methionine synthase ( MS ) and methylmalonyl CoA mutase ( MCM ), which use MeCbl and AdoCbl as cofactors, respectively, bind the cobalamin so that DMB nitrogen is displaced from the cobalt and replaced by a histidine of the enzyme

Melatonin attenuates brain contusion-induced oxidative insult, inactivation of signal transducers and activators of transcription 1, and upregulation of suppressor of cytokine signaling-3 in rats