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Obviously, the pH-sensitive hydrazone provides the release mechanism for doxorubicin

Mice deficient in mdr1a and mdr1b revealed that P-gp knockout was not fatal in mice but likely increased the assimilation and neurotoxicity of various drugs ( mdr1a / mdr1b and mrp1 genes demonstrated that P-gp and MRP1 transporters were responsible for the development of resistance to anthracyclines, taxol, and vinca alkaloids (245)

ClinicalTrials.gov Coskun T, Urva S, Roell WC, et al

neuroinflammation, characterized by the activation of glial cells and altered cytokine profiles

Structural landscape of the 1 : 1 benzoic acid: Isonicotinamide cocrystal
