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Author Models Primary investigations Associated Outcomes Reported Sikiric etal (1997) [46] Male Wistar rats Effect of BPC-157 on induced inflammatory arthritis Reduced paw inflammation, nodule formation, stiffness Sebeci etal (1999) [39] Rabbits Effect of BPC-157 on a rabbit nonunion model Local BPC-157 performed similarly to percutaneous injection of autologous bone marrow or autologous bone grafting in resolving nonunion defect Staresinic etal (2003) [49] Male Wistar rats Effect of BPC-157 on Achilles tendon healing post-transection Improved Achilles tendon structural, functional, and biomechanical indices

Am J Clin Nutr 2010;91:1123S1127S

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Myofibroblasts can be originated from different sources, including tissue resident fibroblasts, epithelial and endothelial cells undergoing epithelial/endothelial-to-mesenchymal transition (EMT/EndMT), as well as from circulating fibroblast-like cells named fibrocytes, originated from bone-marrow stem cells [12]