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Studies indicate that the variability among the three major ApoE isoformsApoE2, ApoE3, and ApoE4is attributable to genetic polymorphisms (Zannis and Breslow, 1981)

Apart from angiogenesis, cancer may achieve new vasculature by vessel co-option (using existing vessels), vascular mimicry (the process of forming vessels from tumor cells) and vasculogenesis (involving bone marrow-derived progenitor cells) (120)

The model quality was check by MolProbity 63

A PubMed literature search used keywords, such as amyotrophic lateral sclerosis or ALS, as well as combinations of words using the controlled vocabulary thesaurus feature, Medical Subject Headings (MeSH)