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Additionally, lactate has been found to stimulate circulating vasculogenic stem cells within subcutaneous matrix tissue via a mechanism dependent on thioredoxin 1 (Trx1) and HIF-1, forming a positive feedback loop [170]

Considerations for Potential Applications of the AOP (optional) Addressess potential applications of an AOP to support regulatory decision-making.This may include, for example, possible utility for test guideline development or refinement, development of integrated testing and assessment approaches, development of (Q)SARs / or chemical profilers to facilitate the grouping of chemicals for subsequent read-across, screening level hazard assessments or even risk assessment

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Understanding these differences is crucial for informed treatment decisions

This process, while seemingly paradoxical, can lead to significant tissue damage and cell death, often exceeding the initial injury caused by ischemia alone[323, 324]