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Conclusions and Recommendations Key messages for at-risk populations: The EVOKE trial failure does not invalidate GLP-1 agonists for preventionthe epidemiological signal remains strong, and these drugs may provide metabolic and cardiovascular benefits with potential cognitive co-benefits when used for approved indications SS-31s approval establishes precedent for mitochondrial-targeted therapeuticswatch this space for expanded indications Popular biohacker peptides (BPC-157, Dihexa, P21) have essentially no human cognitive evidence

The benzyl alcohol inhibits bacterial growth, which means that a reconstituted vial can, in principle, be used across multiple doses over a period of days to weeks rather than being discarded after a single use as would be required with plain sterile water

Williamstown's Addi Kerby (4th, 16.85) and Tyler Consolidated's Addison Blosser (7th, 17.26) also qualified to the finals

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