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The honest boundary is that even the coherent pairing is a mechanistic hypothesis with no human validation, so the most defensible research posture is to study the single compound at its documented dose first, and treat any combination as a further, clearly-labelled research question rather than a default

The combination produces compounding effects on mitochondrial substrate utilization

doi:10.1007/s00198-021-05966-8

doi: 10.1093/humupd/dmac005 106 de RouxNGeninECarelJCMatsudaFChaussainJLMilgromE

Furthermore, the mRNA levels of GATA4 and FOXA2 in Wnt3a-treated cells was significantly higher than in activin A-treated cells (Fig