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In a 2017 systematic review of 18 trials, including 1,143 subjects with rheumatoid arthritis, only 4 of 18 placebo-controlled trials showed a benefit of omega-3 PUFA supplementation (2.2-3.6 g/day for 12-36 weeks) on pain level reported by patients and/or assessed by physicians (158)

Older people can also benefit from L-carnitine supplements

Supplementing with vitamin D has shown some improvements in social interactions and repetitive behaviors

Table 4 also showed that AST and ALT concentrations increased significantly in the CT group, whereas minimal changes in ALT concentration were observed during fasting in the LC group

As with most dietary supplements, it works best when combined with balanced meals, proper hydration, and consistent physical activity