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In addition, oxidation of intracellular GSH to GSSG and subsequent export of GSSG was recently reported for treatments of cultured rat astrocytes with menadione (Arend et al
These results suggested that by preventing Sab phosphorylation, fomepizole interrupted the amplified oxidative stress cycle, stopped ROS production and halted activation of ASK1/2 ( Figure 23 )
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Greenberg P, Tracy JK, Meyer WA et al: Short interval between symptom onset and medical care as an indication of rapid onset of interstitial cystitis/painful bladder syndrome
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