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This oxygen species may penetrate cellular membranes and react with nuclear DNA [7]

However, huC242-SPDB-DM4 exhibited significantly higher activity in multiple xenograft tumor models in vivo

10.1101/2024.08.22.609211 86 OrenY.TsabarM.CuocoM

MAOA up-regulation under androgen deprivation treatment induces mitophagy In addition to regulation of autophagy, increasing evidence has shown that ROS-induced mitochondrial depolarization initiates mitophagy, a selective type of autophagy in which dysfunctional mitochondria are removed by targeting to autophagic degradation 43