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Description
CPI-613 CPI-613 (Figure 6C), a multitargeted metabolic inhibitor derived from endogenous ALA, targets the dysregulated tricarboxylic acid (TCA) cycle in cancer cells by inhibiting both the -ketoglutarate dehydrogenase (KGDH) and pyruvate dehydrogenase complex (PDC), which is currently undergoing clinical trials in various malignancies [84]

this requires employing advanced technologies like high-resolution NMR, cryo-electron microscopy, and AI-assisted modeling to elucidate precise structure-function relationships for the rational design of improved therapeutics

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Proc Natl Acad Sci USA 103(35):1308613091
