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CPI-613 CPI-613 (Figure 6C), a multitargeted metabolic inhibitor derived from endogenous ALA, targets the dysregulated tricarboxylic acid (TCA) cycle in cancer cells by inhibiting both the -ketoglutarate dehydrogenase (KGDH) and pyruvate dehydrogenase complex (PDC), which is currently undergoing clinical trials in various malignancies [84]

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this requires employing advanced technologies like high-resolution NMR, cryo-electron microscopy, and AI-assisted modeling to elucidate precise structure-function relationships for the rational design of improved therapeutics

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Proc Staff Meet Mayo Clin 1956

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This gives you the power to choose your medical care in a safe and informed manner.

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Proc Natl Acad Sci USA 103(35):1308613091

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