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Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis

Kang S, Krueger GG, Tanghetti EA, et al

T cell exhaustion is characterized functionally by a decline in cytokines like interleukin-2 (IL-2), reduced proliferative and cytotoxic capacity, impaired pro-inflammatory cytokine production like tumor necrosis factor, and a decrease in the proliferative potential after antigen exposure in vitro [46,47,48]

We talk about the origins of this anthology & how it transformed into a three-part series (two more coming next year!), Phillips self-admitted megalomania about the essay form, how the essay both paralleled and helped change American thought over the centuries, and just whats so Glorious about The Glorious American Essay

Although a Rieske-type microbial CntA / B enzyme was proposed to convert carnitine to TMA [20], recent studies argued against its role in TMA synthesis from carnitine in the human gut [11, 21]